Never owned or driven a VFR but I suspect the issues is reduced weight and top speed much slower. I prefer lighter bikes myself as the handling is easier in most speeds. Top speed is fast enough, I only need to get up to 75-80mph with my 500F the few times I need to overtake a truck on a bigger California highway.
I did a 9am to 5pm trip yesterday, over Mount Hamilton and across the fields to Merced and back to San Jose. The only thing that was fatigued was me, not the bike. 71 miles/gallon is also nice. I only had to stop for gas for stretching my legs.